Cymbalta Capsules

Cymbalta Delayed-Release Capsules is used for:

Treating depression and generalized anxiety disorder. It is used for managing pain caused by fibromyalgia and diabetic peripheral neuropathy (DPNP). It may also be used for other conditions as determined by your doctor.

Cymbalta Delayed-Release Capsules is a serotonin and norepinephrine reuptake inhibitor (SNRI). It works by restoring the balance of certain natural substances in the brain (serotonin and norepinephrine), which helps to improve certain mood problems.

Do NOT use Cymbalta Delayed-Release Capsules if:

• you are allergic to any ingredient in Cymbalta Delayed-Release Capsules
• you have uncontrolled narrow-angle glaucoma
• you have liver problems or severe kidney problems, or you are having dialysis
• you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
• you are taking a quinolone antibiotic (eg, ciprofloxacin), a selective serotonin reuptake inhibitor (SSRI) (eg, fluoxetine, fluvoxamine), an SNRI (eg, venlafaxine), thioridazine, or tryptophan

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cymbalta Delayed-Release Capsules:

Some medical conditions may interact with Cymbalta Delayed-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse
• if you have a history of seizures, heart problems (eg, heart failure, irregular heartbeat), recent heart attack, high blood pressure, kidney problems, diabetes, stomach or bowel problems (eg, slowed emptying), or increased eye pressure (eg, glaucoma)
• if you are dehydrated, have low blood sodium levels, or drink alcohol

Some MEDICINES MAY INTERACT with Cymbalta Delayed-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• 5-HT₁ receptor agonists (eg, sumatriptan), linezolid, lithium, MAOIs (eg, phenelzine), quinidine, rasagiline, SNRIs (eg, venlafaxine), SSRIs (eg, fluoxetine, fluvoxamine), St. John's wort, tramadol, or tryptophan because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur
• Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased
• Cimetidine, medicines for high blood pressure, or quinolone antibiotics (eg, ciprofloxacin) because they may increase the risk of Cymbalta Delayed -Release Capsules's side effects
• Certain antiarrhythmics (eg, flecainide, propafenone), phenothiazines (eg, chlorpromazine, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Cymbalta Delayed-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cymbalta Delayed-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.