Estradiol Valerate

Estradiol Valerate is used for:

Treating certain symptoms of menopause (eg, hot flashes, vaginal itching, burning, or dryness). It is used to treat low levels of estrogen caused by certain conditions. It may be used to treat certain types of prostate cancer (advanced androgen-dependent). It may also be used for other conditions as determined by your doctor.

Estradiol Valerate is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.It works for advanced prostate cancer by antagonizing male hormones.

Do NOT use Estradiol Valerate if:

• you are allergic to any ingredient in Estradiol Valerate
• you are pregnant or suspect you may be pregnant, or you have vaginal bleeding of abnormal or unknown cause
• you have a history of known or suspected breast cancer (unless your doctor tells you otherwise)
• you have any other estrogen-dependent cancer
• you have the blood disease porphyria, or a history of blood clots or liver problems
• you have had a recent (within the past year) stroke or heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Estradiol Valerate :

Some medical conditions may interact with Estradiol Valerate . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have breast lumps or disease, an abnormal mammogram, or a family history of breast cancer or blood clots
• if you have yellowing of the skin or whites of the eyes during pregnancy or with past estrogen use, or high blood pressure during pregnancy (toxemia)
• if you have a vaginal infection or womb problems (eg, uterine fibroids/endometriosis, abnormal vaginal bleeding, other uterine problems)
• if you have abnormal calcium levels in the blood, asthma, cancer, cholesterol or lipid problems, depression, diabetes, epilepsy, excessive weight gain, gallbladder disease, heart disease or other heart problems, high blood pressure, kidney or liver disease, low thyroid hormone levels, lupus, migraine headaches, pancreas disease, seizures, or yellowing of the skin or eyes
• if you smoke, are overweight, or will be having surgery
• if you have a history of alcohol or other substance abuse or dependence

Some MEDICINES MAY INTERACT with Estradiol Valerate . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, or tacrine because their actions and side effects may be increased by Estradiol Valerate
• Anticoagulants (eg, warfarin) because thei r effectiveness may be decreased by Estradiol Valerate
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), carbamazepine, rifampin, or St. John's wort because they may decrease Estradiol Valerate 's effectiveness
• Azole antifungals (eg, ketoconazole) or macrolide antibiotics (eg, erythromycin) because they may increase the risk of Estradiol Valerate 's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Estradiol Valerate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.