Climara Weekly Patch

Climara Weekly Patch should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use Climara Weekly Patch. Talk with your doctor if you have questions about the benefits and risks of using Climara Weekly Patch.

Climara Weekly Patch should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use Climara Weekly Patch.

Climara Weekly Patch is used for:

Treating conditions due to menopause (eg, hot flashes; vaginal itching, burning, or dryness), treating vulvar and vaginal atrophy, and preventing osteoporosis. It is also used for estrogen replacement therapy after failure of the ovaries and to relieve symptoms of breast cancer.

Climara Weekly Patch is an estrogen hormone used to provide the female hormone when the body no longer produces enough.

Do NOT use Climara Weekly Patch if:

• you are allergic to any ingredient in Climara Weekly Patch
• you are pregnant or suspect you may be pregnant, have recently given birth or are breast-feeding, have vaginal bleeding of abnormal or unknown cause, or have cancer of the uterus
• you have known or suspected breast cancer (unless directed by your doctor), or you have cancers that are estrogen-dependent
• you have blood clots, circulation disorders, or liver problems
• you have had a recent heart attack or stroke

Contact your doctor or health care provider right away if any of these apply to you.

Before using Climara Weekly Patch:

Some medical conditions may interact with Climara Weekly Patch. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a family history of breast cancer, or you have breast lumps or disease, or an abnormal mammogram
• if you have yellowing of the whites of the eyes or skin during pregnancy or with past estrogen use, or high blood pressure during pregnancy (toxemia)
• if you have a vaginal infection or womb problems (eg, uterine fibroids/endometriosis, abnormal vaginal bleeding, other uterine problems)
• if you have abnormal calcium levels in the blood, asthma, cancer, certain blood disorder (porphyria), cholesterol or lipid problems, depression, diabetes, epilepsy, excessive weight gain, gallbladder disease, heart disease or other heart problems, high blood pressure, kidney or liver disease, low thyroid hormone levels, lupus, migraine headaches, pancreas disease, seizures, or yellowing of the skin or eyes
• if you smoke or will be having surgery

Some MEDICINES MAY INTERACT with Climara Weekly Patch. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, tacrine or because their actions and the risk of their side effects may be increased by Climara Weekly Patch
• Anticoagulants (eg, warfarin) because their effectiveness may be decreased by Climara Weekly Patch
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin because they may decrease Climara Weekly Patch's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Climara Weekly Patch may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.